A few months ago, I wrote a post detailing why the oft-repeated suggestion of 6-8 small meals a day is disastrous. In short, the pancreas is designed to release insulin 2-3 times a day. Anytime food enters the system, the pancreas releases insulin. As such, the 6-8 meals per day overworks the pancreas. In fact, some researchers (such as Dr. Brian Peskin) suggest that this way of eating actually is one of the causes of diabetes. In my experiences with patients over the years, I would agree with this theory.
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